Pubblicazioni Scientifiche

Helios Med Onlus è attiva nel campo della ricerca ed è specializzata sulla cura dell'ulcera diabetica e dell'ulcera di Buruli.

Ulcère de Buruli: des horizons thérapeutiques en hôpital et en brousse

Maria Letizia IABICHELLA, Olivier SALMON, Antonella BERTOLOTTI, Annunziata IZZO, Valentina FUSARI, Marzia LUGLI

Buruli Ulcer (BU) is caused by Micobacterium Ulcerans, being a rapidly growing pathology in many countries of the tropical and subtropical area of Africa. Even if vectors and transmitters are yet unknown, it is supposed that transmission is associated with water human activities or linked with soil utilization. These hypotheses are sustained by the results performed locally, especially in villages. Aim of this study is to estimate the incidence of BU in an isolated area of Benin (Zinvié) and to evaluate pathology characteristics, therapy used and their outcomes.

The Use of a Mixture of Hypericum Perforatum and Azadirachta indica for the Management of Diabetic Foot Ulcers: A Case Series

Maria Letizia IABICHELLA

Diabetic foot ulcers (DFU) represent a growing health care issue worldwide, representing one of the most dramatic consequences of poorly controlled diabetes. A first successful experience on a patient with extremely advanced feet ulcers treated with a mixture of Hypericum perforatum and Azadirachta indica (Hyperoil™) has induced us to use the same treatment on a series of patients with less severe ulcers. Aim of this report is to summarize the results observed in this case series.

In vitro Bacteriostatic Effect of a Scaffold with a Mixture of Hypericum perforatum and Azadirachta indica Oil Extracts

Maria Letizia IABICHELLA

Clinical evidences suggest antimicrobial activities of a new oil extract mixture of Hypericum perforatum and Azadirachta indica, included in a polymeric scaffold (or Hyperoil™ Polimeric Substrate - HPS).

The use of an extract of Hypericum perforatum and Azadirachta indica in a neuropathic patient with advanced diabetic foot

Maria Letizia IABICHELLA, Claudio CARUSO, Marzia LUGLI

The successful use of an extract of Hypericum flowers (Hypericum perforatum) and nimh oil (Azadirachta indica; Hyperoil) in foot wounds with exposed bone in a patient with bilateral advanced diabetic ulcers, has been reported previously. It was hypothesised that this amelioration was linked with the improved glycaemic control and peripheral microvascular circulation. In this case report, the surprisingly successful outcome of another patient using Hyperoil for infection damaged diabetic foot, without prior use of surgical procedure, is described. The patient had no macrovascular pattern impairment. Diabetic foot healing paralleled with controlled local infection and enhanced glycaemic control. The outcome of this patient suggests that the effectiveness of this inexpensive therapy using Hyperoil for diabetic foot is not only linked with the presence of severe microvascular disorder, but also with the appropriate local treatment for ulcer being a must for its recovery.

Localized Treatment of Chronic Buruli Ulcer with Hyperoil™: An Unexpected Outcome

Maria Letizia IABICHELLA, Malgorzata TOPOLINSKA, Cyprien AMAKU ANZAKO

The successful sustained outcome of this patient with chronic Buruli Ulcer treated with Hyperoil™, suggests its use for local treatment of infected ulcers with bone exposition. Hyperoil™ use could be particularly effective in endemic areas, far from specialized centers, where African populations living in poor rural areas are more difficult to be treated.

The use of an extract of Hypericum perforatum and Azadirachta indica in advanced diabetic foot: an unexpected outcome

Maria Letizia IABICHELLA

This is the first case reporting the results of using an extract of Hypericum flowers (Hypericum perforatum) and neem oil (Azadirachta indica) in foot wounds with exposed bone in a patient with bilateral advanced diabetic ulcers. The effective use of this cheap treatment in patients with diabetic lesions on the feet, if confirmed in a wide controlled study, might allow the caregivers to take care of patients at home.